University Clinic Bonn Institute of Experimental Haematology and Transfusion Medicine Director: Prof. Dr. Johannes Oldenburg
F13 Genes

There are two FXIII genes: F13A gene encodes FXIIIA-Subunit and F13B gene encodes FXIIIB-Subunit. F13A gene was found on chromosome 6 at bands p24-25 (Board et al 1988). It contains 15 exons separated by 14 introns and belongs to a family of transglutaminases (Ichinose et al 1988). F13A exons vary considerably in size, ranging from 83 (exon 1) to 1688 (exon 15) nucleotides (see table 1). The F13B gene is located on the long arm of chromosome 1 (q32-32.1) (Webb et al 1989). It is composed of 12 exons interrupted by 11 introns (see table 2) (Bottenus et al 1990).


Size of F13A Exons and Introns
Exon Size (bp) Intron Size (kb)
Exon 1 83 Intron 1 <1,9
Exon 2 148 Intron 2 1,3
Exon 3 189 Intron 3 38,5
Exon 4 252 Intron 4 15,6
Exon 5 119 Intron 5 2,4
Exon 6 108 Intron 6 23,5
Exon 7 175 Intron 7 2,5
Exon 8 139 Intron 8 24,7
Exon 9 104 Intron 9 1,3
Exon 10 89 Intron 10 13,6
Exon 11 154 Intron 11 7,1
Exon 12 288 Intron 12 7
Exon 13 161 Intron 13 15,5
Exon 14 137 Intron 14 6
Exon 15 1688

Table 1. Size of F13A exons and introns.

 

Size of F13B Exons and Introns
Exon Size (bp) Intron Size (kb)
Exon 1 >76 Intron 1 4098
Exon 2 201 Intron 2 887
Exon 3 186 Intron 3 707
Exon 4 177 Intron 4 356
Exon 5 177 Intron 5 2901
Exon 6 180 Intron 6 87
Exon 7 186 Intron 7 1114
Exon 8 183 Intron 8 2874
Exon 9 201 Intron 9 1755
Exon 10 183 Intron 10 9952
Exon 11 214 Intron 11 1110
Exon 12 221

Table 2. Size of F13B exons and introns.